Using AI-generated output in a work does not necessarily prevent registration of a copyright in the work. If a work is entirely AI-generated, then yes, copyright protection cannot be claimed. This is true even if a human provided the prompts for the output. If the output contains significant human-authored expression, however, a claim of copyright may still be made. For example, if a human writes a story and prompts an AI tool to edit it, copyright may still be claimed in the story. In addition, if a human makes substantial creative and original modifications to AI-generated output, copyright may be claimed in those modifications. And copyright may be claimed in a human’s selection, coordination and arrangement of AI-generated elements even though copyrights in the AI-generated elements themselves must be disclaimed.