Yes. The USPTO can cancel a registration for a particular class or classes of goods or services while leaving the registration intact for another class or classes of goods or services. The Trademark Modernization Act allows the USPTO to expunge or reexamine specific classes of claimed use that lack evidence of actual and continuing use in commerce. The registrant may also voluntarily surrender particular classes if the trademark was never used, or is no longer being used, for those classes of goods or services. If the mark was never used for that class, the proceeding is called expungement. If it was being used at one time but is no longer being used, or is not in use by the required date, it is called reexamination.
Alternatively, a cancellation petition may be filed by the USPTO or an interested party with the Trademark Trial and Appeal Board (TTAB) to challenge a registration on the grounds of non-use or abandonment for specific class(es).
Cancellation may be of the entire registration or it may be a partial cancellation applicable only to a particular class or classes of goods or services. Non-use is not the only basis for cancellation. Genericide, loss of distinctiveness, and likelihood of confusion as to a particular class of goods or services may also furnish grounds for cancellation.